>80%
Tests confirm that more than 80% of the product dissolves within just 45 minutes, allowing the body to absorb and utilize it rapidly.
18 subject
A total of 18 articles have been published in leading global Q1 (Quartile 1) academic journals.
714+
It has been cited more than 714 times by researchers worldwide (as of March 2026).
10 mg/capsule
The amount of the active ingredient, andrographolide, is controlled to be consistent at 10 milligrams per capsule, ensuring that consumers receive the same amount of active ingredient every time they take the medication.
Source
The project's origins lie in the 1999 Science Congress, when His Majesty King Bhumibol Adulyadej (Rama IX) gave a royal address emphasizing the need to bring science and technology to the grassroots level in a tangible way. This led to the creation of the PC-1999 project, an innovation in Thai herbal medicine meeting international standards.
Start research and development.
The Chulabhorn Research Institute initiated a herbal cultivation project at Thap Thim Siam 05 Village, Khlong Kai Thuean Subdistrict, Khlong Hat District, Sa Kaeo Province in 1999. The project gained recognition for its adherence to Good Agricultural Practice (GAP) standards in herbal production. Subsequently, it studied Andrographis paniculata, focusing on optimal harvesting times, the stability of active compounds, and the development of analytical methods for four specific active compounds.
The process of extracting Andrographis paniculata with water.
The Chulabhorn Research Institute designed an aqueous extraction method, drawing inspiration from the traditional Thai herbal medicine boiling technique, to obtain highly effective active ingredients. The institute then transferred this production technology to Pana Osoth Co., Ltd., a GMP ASEAN certified herbal medicine manufacturing plant, for the industrial-scale production of the PC-1999 product.
Product manufacturing and quality standards.
The research on Andrographis paniculata conducted by the Chulabhorn Research Institute has received recognition both domestically and internationally. Research articles have been published in several leading journals and are cited in research worldwide. This makes PC-1999 more than just a typical herbal medicine, but a clear example of "Thai herbal medicine that has undergone systematic research and quality control" to international standards.
6 Key Differentiators from the Market
It's not a typical herbal medicine, but rather an example of...
"Thai herbal medicines that have undergone systematic research and quality control."
The first water-based extract innovation in Thailand.
Developed by Chulabhorn Research Institute, this extraction technique uses water for better absorption into the bloodstream compared to conventional alcohol extraction.
Guaranteed by national awards.
National Research Award 2024
It has a "very good" rating and is supported by 18 research papers published in international academic journals.
Fast-acting, immediate results.
Dissolution tests showed that more than 80% of the active ingredients could be released within just 45 minutes.
Clean, safe, and meets international standards.
Comprehensive quality control, from GAP-certified organic raw materials to GMP PIC/S certified production processes.
Accurate standards for key ingredients.
Quality control ensures a consistent amount of andrographolide (10 mg) per capsule, guaranteeing effectiveness in every tablet.
Register the medicine properly.
Registered as a commercially available herbal medicine.
Registration number G 616/65, for fever relief, by the Thai Food and Drug Administration (FDA).
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